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1

Molecular etiology of gut malformations and diseases

Pascal De Santa Barbara, Gijs Robert Van Den Brink, Drucilla Jane Roberts

Journal:

American Journal of Medical Genetics Part A

Year:

2002

Language:

english

File:

PDF, 131 KB

english, 2002

2

Leptin Signaling in Human Peripheral Blood Mononuclear Cells, Activation of p38 and p42/44 Mitogen-Activated Protein (MAP) Kinase and p70 S6 Kinase

Gijs R. van den Brink, Tom O'Toole, James C.H. Hardwick, Daniëlle E.M. van den Boogaardt, Henri H. Versteeg, Sander J.H. van Deventer, Maikel P. Peppelenbosch

Journal:

Molecular Cell Biology Research Communications

Year:

2000

Language:

english

File:

PDF, 213 KB

english, 2000

3

Study of calcium signaling in non-excitable cells

Van Den Brink, Gijs R., Bloemers, S. Margreet, Van Den Blink, Bernt, Tertoolen, Leon G.J., Van Deventer, Sander J.H., Peppelenbosch, Maikel P.

Journal:

Microscopy Research and Technique

Year:

1999

Language:

english

File:

PDF, 831 KB

english, 1999

4

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer

Liudmila L. Kodach, Sylvia A. Bleuming, Alex R. Musler, Maikel P. Peppelenbosch, Daniel W. Hommes, Gijs R. van den Brink, Carel J. M. van Noesel, G. Johan A. Offerhaus, James C. H. Hardwick

Journal:

Year:

2008

Language:

english

File:

PDF, 273 KB

english, 2008

5

Quality of web-based information on inflammatory bowel diseases

Sander van der Marel, Marjolijn Duijvestein, James C. Hardwick, Gijs R. van den Brink, Roeland Veenendaal, Daniel W. Hommes, Herma H. Fidder

Journal:

Inflammatory Bowel Diseases

Year:

2009

Language:

english

File:

PDF, 160 KB

english, 2009

6

Neutralizing antibodies against adeno-associated viruses in inflammatory bowel disease patients: Implications for gene therapy

Sander van der Marel, Elisabeth M. Comijn, Hein W. Verspaget, Sander van Deventer, Gijs R. van den Brink, Harald Petry, Daniel W. Hommes, Valerie Ferreira

Journal:

Inflammatory Bowel Diseases

Year:

2011

Language:

english

File:

PDF, 344 KB

english, 2011

7

Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro

Anne Christine W. Vos, Manon E. Wildenberg, Ingrid Arijs, Marjolijn Duijvestein, Auke P. Verhaar, Gert de Hertogh, Séverine Vermeire, Paul Rutgeerts, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Inflammatory Bowel Diseases

Year:

2012

Language:

english

File:

PDF, 1.40 MB

english, 2012

8

The absence of functional PI3Kγ prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice

Willemijn A. van Dop, Stefano Marengo, Anje A. te Velde, Elisa Ciraolo, Irene Franco, Fiebo J. ten Kate, Guy E. Boeckxstaens, James C. Hardwick, Daan W. Hommes, Emilio Hirsch, Gijs R. van den Brink

Journal:

Immunology Letters

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

9

Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils

Hidekazu Suzuki, Yuriko Minegishi, Yohei Nomoto, Takayuki Ota, Tatsuhiro Masaoka, Gijs R van den Brink, Toshifumi Hibi

Journal:

The Journal of Pathology

Year:

2005

Language:

english

File:

PDF, 940 KB

english, 2005

10

From Extracellular to Intracellular Targets, Inhibiting MAP Kinases in Treatment of Crohn's Disease

BERNT VAN DEN BLINK, TESSA ten HOVE, GIJS R. VAN DEN BRINK, MAIKEL P. PEPPELENBOSCH, SANDER J.H. VAN DEVENTER

Journal:

Annals of the New York Academy of Sciences

Year:

2002

File:

PDF, 902 KB

2002

11

Hh pathway expression in human gut tissues and in inflammatory gut diseases

Nielsen, Corinne M, Williams, Jerrell, van den Brink, Gijs R, Lauwers, Gregory Y, Roberts, Drucilla J

Journal:

Laboratory Investigation

Year:

2004

Language:

english

File:

PDF, 1.13 MB

english, 2004

12

Linking pathways in colorectal cancer

van den Brink, Gijs R

Journal:

Nature Genetics

Year:

2004

Language:

english

File:

PDF, 97 KB

english, 2004

13

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

van den Brink, Gijs R, Bleuming, Sylvia A, Hardwick, James C H, Schepman, Berber L, Offerhaus, G Johan, Keller, Josbert J, Nielsen, Corinne, Gaffield, William, van Deventer, Sander J H, Roberts, Druci

Journal:

Nature Genetics

Year:

2004

Language:

english

File:

PDF, 2.74 MB

english, 2004

14

Bone morphogenetic protein signalling in colorectal cancer

Hardwick, James C., Kodach, Liudmila L., Offerhaus, G. Johan, van den Brink, Gijs R.

Journal:

Nature Reviews Cancer

Year:

2008

Language:

english

File:

PDF, 510 KB

english, 2008

15

NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps

Hardwick, James CH, van den Brink, Gijs R, Offerhaus, G J, van Deventer, Sander JH, Peppelenbosch, Maikel P

Journal:

Year:

2001

Language:

english

File:

PDF, 1.92 MB

english, 2001

16

The Morphogenetic Code and Colon Cancer Development

Gijs R. van den Brink, G. Johan Offerhaus

Journal:

Year:

2007

Language:

english

File:

PDF, 1.16 MB

english, 2007

17

Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression

Mark Löwenberg, Auke P. Verhaar, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Trends in Molecular Medicine

Year:

2007

Language:

english

File:

PDF, 462 KB

english, 2007

18

Conscious sedation for EUS of the esophagus and stomach: A double-blind, randomized, controlled trial comparing midazolam with placebo

Peter I. Bonta, Maarten F. Kok, Jacques J.G.H.M. Bergman, Gijs R. Van den Brink, Jorrit S. Lemkes, Guido N.J. Tytgat, Paul Fockens

Journal:

Gastrointestinal Endoscopy

Year:

2003

Language:

english

File:

PDF, 86 KB

english, 2003

19

Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn’s disease

Jan M.H Van den Brande, Henri Braat, Gijs R van den Brink, Henri H Versteeg, Christiaan A Bauer, Inge Hoedemaeker, Catherine van Montfrans, Daan W Hommes, Maikel P Peppelenbosch, Sander J.H van Devent

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 322 KB

english, 2003

20

Expression of sonic hedgehog in the human and mouse stomach, a possible as a gastric epithelial morphostal

Gijs R. Van Den Brink, James C.H. Hardwick, Guido N.J. Tytgat, Menno A. Brink, Fiebo J. Ten Kate, Sander J.H. Van Deventer, Maikel P. Peppelenbosch

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

21

351 Lovastatin Acts As Demethylating Agent in Colorectal Cancer Cell Lines

Liudmila L. Kodach, Rutger Jacobs, Maikel P. Peppelenbosch, Daniel Hommes, Gijs R. van den Brink, James C. Hardwick

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 121 KB

english, 2009

22

1093 The Absence of Functional PI3Kγ Has a Protective Effect On DSS-Induced Colitis in Mice

Willemijn A. van Dop, Stefano Marengo, Anje A. Te Velde, Fiebo J. ten Kate, Daniel Hommes, Guy E. Boeckxstaens, Emilio Hirsch, Gijs R. van den Brink

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 74 KB

english, 2009

23

87 Conditional Loss of Intestinal Hedgehog Signaling Results in a Regenerative Response and Subsequently in Loss of Villi and the Spontaneous Development of Chronic Enteritis

Willemijn A. van Dop, Elisabeth A. Wassenberg, Beate Lanske, Alan R. Clarke, Johan Offerhaus, Daniel W. Hommes, James C. Hardwick, Izak Biemond, Gijs R. van den Brink

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 53 KB

english, 2010

24

186 Constitutive Hedgehog Signaling Impairs Maturation and Migration of Esophageal Epithelial Precursor Cells

Willemijn A. van Dop, Anja Uhmann, Viljar Jaks, Johan Offerhaus, Marius A. van den Bergh Weerman, Jarom Heijmans, Daniel W. Hommes, James C. Hardwick, Rune Toftgård, Heidi Hahn, Gijs R. van den Brink

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 46 KB

english, 2010

25

1019 ATG16L1 and IRGM Contribute to the Regulation of Immune Responses

Manon E. Wildenberg, Anne Christine W. Vos, Marjolijn Duijvestein, Auke Verhaar, Caterina Strisciuglio, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 50 KB

english, 2010

26

Statins Reduce the Risk on Colorectal Cancer in Relation to SMAD4 Expression

Rutger J. Jacobs, Liudmila L. Kodach, Nikki L. Weil, Philip W. Voorneveld, Mariel Casparie, Ron M. Herings, Hans Morreau, Gijs R. van den Brink, Daniel W. Hommes, James C. Hardwick

Journal:

Gastroenterology

Year:

2011

Language:

english

File:

PDF, 47 KB

english, 2011

27

Autophagy Regulates Immune Responses Through Destabilization of the Immunological Synapse

Manon E. Wildenberg, Anne Christine W. Vos, Simone C. Wolfkamp, Marjolijn Duijvestein, Auke Verhaar, Anje A. Te Velde, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Gastroenterology

Year:

2011

Language:

english

File:

PDF, 175 KB

english, 2011

28

407 Rock-Inhibitors Reduce the Induction of Epithelial to Mesenchymal Transition, Migration and Invasion Caused by Bone Morphogentic Protein Signaling in SMAD4 Deficient Colorectal Cancers

Philip Voorneveld, Liudmila L. Kodach, Rutger J. Jacobs, Gijs R. van den Brink, Daniel W. Hommes, Maikel P. Peppelenbosch, James C. Hardwick

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 65 KB

english, 2012

29

646 Statins Inhibit the PI3K/AKT/mTOR Pathway in Colorectal Cancer Through Upregulation of PTEN in a BMP Dependent Manner

Rutger J. Jacobs, Liudmila L. Kodach, Philip Voorneveld, Jarom Heijmans, Sander H. Diks, Gijs R. van den Brink, Daniel W Hommes, Maikel P. Peppelenbosch, James C. Hardwick

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 66 KB

english, 2012

30

Leptin Is a Growth Factor for Colonic Epithelial Cells

James C.H. Hardwick, Gijs R. Van Den Brink, G.J. Offerhaus, Sander J.H. Van Deventer, Maikel P. Peppelenbosch

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 968 KB

english, 2001

31

Sonic Hedgehog Regulates Gastric Gland Morphogenesis in Man and Mouse

Gijs R. Van den Brink, James C.H. Hardwick, Guido N.J. Tytgat, Menno A. Brink, Fiebo J. Ten Kate, Sander J.H. Van Deventer, Maikel P. Peppelenbosch

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 1019 KB

english, 2001

32

Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon

James C.H. Hardwick, Gijs R. Van Den Brink, Sylvia A. Bleuming, Isabel Ballester, Jan.M.H. Van Den Brande, Josbert J. Keller, G.Johan A. Offerhaus, Sander J.H. Van Deventer, Maikel P. Peppelenbosch

Journal:

Gastroenterology

Year:

2004

Language:

english

File:

PDF, 1.04 MB

english, 2004

33

Expression of Hedgehog Pathway Components in the Adult Colon

Gijs R. Van Den Brink, Maikel P. Peppelenbosch

Journal:

Gastroenterology

Year:

2006

Language:

english

File:

PDF, 61 KB

english, 2006

34

The Effect of Statins in Colorectal Cancer Is Mediated Through the Bone Morphogenetic Protein Pathway

Liudmila L. Kodach, Sylvia A. Bleuming, Maikel P. Peppelenbosch, Daniel W. Hommes, Gijs R. van den Brink, James C.H. Hardwick

Journal:

Gastroenterology

Year:

2007

Language:

english

File:

PDF, 2.73 MB

english, 2007

35

The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers

Liudmila L. Kodach, Eliza Wiercinska, Noel F.C.C. de Miranda, Sylvia A. Bleuming, Alex R. Musler, Maikel P. Peppelenbosch, Evelien Dekker, Gijs R. van den Brink, Carel J.M. van Noesel, Hans Morreau, D

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 4.62 MB

english, 2008

36

Sonic Hedgehog: A Link Between Inflammation, Gastric Atrophy, and Acid Suppression?

Willemijn A. Van Dop, Gijs R. Van Den Brink

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 428 KB

english, 2010

37

Anti–Tumor Necrosis Factor-α Antibodies Induce Regulatory Macrophages in an Fc Region-Dependent Manner

Anne Christine W. Vos, Manon E. Wildenberg, Marjolijn Duijvestein, Auke P. Verhaar, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Gastroenterology

Year:

2011

Language:

english

File:

PDF, 1.49 MB

english, 2011

38

Morphogens and the Parietal Cell: Shaping Up Acid Secretion

Jarom Heijmans, Gijs R. van den Brink

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 960 KB

english, 2010

39

Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse

Manon E. Wildenberg, Anne Christine W. Vos, Simone C.S. Wolfkamp, Marjolijn Duijvestein, Auke P. Verhaar, Anje A. Te Velde, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 3.76 MB

english, 2012

40

Foxf2: A Mesenchymal Regulator of Intestinal Adenoma Development

van den Brink, Gijs R., Rubin, Deborah C.

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 667 KB

english, 2013

41

Vitamin D deficiency in Crohn's disease and healthy controls: A prospective case–control study in the Netherlands

de Bruyn, Jessica R., van Heeckeren, Rosanne, Ponsioen, Cyriel Y., van den Brink, Gijs R., Löwenberg, Mark, Bredenoord, Albert J., Frijstein, Gerard, D’Haens, Geert R.

Journal:

Journal of Crohn's and Colitis

Year:

2014

Language:

english

File:

PDF, 336 KB

english, 2014

42

M1189 Statin Treatment of Colon Cancer Cells Leads to an Overall Downregulation of Receptor Tyrosine Kinase Activity

Jacobs, Rutger J., Kodach, Liudmila L., Diks, Sander H., Heijmans, Jarom, Hommes, Daniel W., van den Brink, Gijs R., Peppelenbosch, Maikel P., Hardwick, James C.

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 51 KB

english, 2010

43

Tu1679 Vitamin D Potentiates the Immunosuppressive Effect of Anti-TNF Induced Regulatory Macrophages

Levin, Alon D., Wildenberg, Manon, Vos, Anne Christine, de Bruyn, Jessica R., Brandse, Johannan F., D'Haens, Geert R., van den Brink, Gijs R.

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 58 KB

english, 2013

44

W1806 Anti-TNF Induced Inhibition of T Cell Proliferation in a Mixed Lymphocyte Reaction is FC Receptor Dependent

Vos, Anne Christine W., Wildenberg, Manon E., Duijvestein, Marjolijn, Verhaar, Auke, Heijmans, Jarom, van den Brink, Gijs R., Hommes, Daniel W.

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 67 KB

english, 2010

45

Mo1693 FcR-Mediated Effector Function Contributes to the Therapeutic Response of Anti-TNF Monoclonal Antibodies in a Mouse Model of IBD

Levin, Alon D., Wildenberg, Manon E., D'Haens, Geert R., van den Brink, Gijs R.

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 305 KB

english, 2014

46

212 Serum CRP Is a Better Early Marker for Response to Infliximab Induction Therapy Than Fecal Calprotectin in Patients With Moderate to Severe Ulcerative Colitis

Brandse, Johannan F., Jansen, Jeroen M., Baars, Paul A., Lowenberg, M., Ponsioen, Cyriel, van den Brink, Gijs R., D'Haens, Geert R.

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 496 KB

english, 2014

47

Sa1207 Leukocyte Scintigraphy As a Tool to Measure Inflammatory Load in Ulcerative Colitis

Brandse, Johannan F., Bennink, Roelof J., Van Eeden, Susanne, Baars, Paul A., Lowenberg, M., Ponsioen, Cyriel, van den Brink, Gijs R., D'Haens, Geert R.

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 133 KB

english, 2014

48

Tu1971 Anti-TNF Induced Regulatory Macrophages Display High Levels of Autophagy

Vos, Anne Christine, Wildenberg, Manon, Levin, Alon D., van den Brink, Gijs R., Hommes, Daniel W.

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 64 KB

english, 2012

49

Su1209 Reduced Length of Hospitalisation and Treatment Costs With Infliximab Versus Ciclosporin in Patients With Severe Ulcerative Colitis

Lowenberg, M., Duijvis, Nicolette W., Ponsioen, Cyriel, van den Brink, Gijs R., Bemelman, Willem A., Fockens, Paul, D'Haens, Geert R.

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 166 KB

english, 2013

50

Tu1655 ER Stress Depletes APC Mutant Intestinal Epithelial Stem Cells Downstream of Nuclear β-Catenin

van Lidth de Jeude, Jooske F., Wielenga, Mattheus C., Rosekrans, Sanne, Muncan, Vanesa, van den Brink, Gijs R., Heijman, Jarom

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 50 KB

english, 2014

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